Steroid disulfates - Sulfation double trouble
نویسندگان
چکیده
Sulfation pathways have recently come into the focus of biomedical research. For steroid hormones and related compounds, sulfation represents an additional layer regulation as sulfated steroids are more water-soluble tend to be biologically less active. diols, is possible, carried out by same sulfotransferases that catalyze first step. The disulfates formed this review. We discuss both their biochemical production well putative biological function. Steroid also been linked various clinical conditions in numerous untargeted metabolomics studies. New analytical techniques exploring biosynthetic routes led novel insights, changing our understanding human biology. They promise a bright future for research pathways, hopefully too diagnosis treatment several associated diseases.
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2021
ISSN: ['0303-7207', '1872-8057']
DOI: https://doi.org/10.1016/j.mce.2021.111161